Life Sci. 1991;49(24):1809-14.

Use of naloxone in the assessment of opiate dependence.

Fudala PJ, Berkow LC, Fralich JL, Johnson RE.

Source

National Institute on Drug Abuse, Addiction Research Center, Baltimore, Md. 21224.

Abstract

All subjects participating in an outpatient study comparing treatments for opiate dependence were given a naloxone challenge to document their level of dependence. Subjects were assessed at 0, 10, 20, and 30 minutes following the administration of intramuscular naloxone (0.4 mg) using an opiate withdrawal assessment scale and measurements of pupillary diameter. Subjects' self reports of daily dollar amounts of opiate use and time since last use were also examined for possible correlation with withdrawal scale scores and pupillary measurements. A significant negative correlation was obtained between pupil diameter and time since last reported use of an opiate. Results indicated that the scale was a reliable indicator of opiate dependence. Ways in which it might be improved are discussed.

PMID:: 1943484; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Naloxone

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

NALOXONE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Naloxone applied to conjunctiva as a test for physical opiate dependence. [Lancet. 1989]
Naloxone applied to conjunctiva as a test for physical opiate dependence.
Creighton FJ, Ghodse AH. Lancet. 1989 Apr 8; 1(8641):748-50.
Nasal administration of naloxone for detection of opiate dependence. [J Psychiatr Res. 1992]
Nasal administration of naloxone for detection of opiate dependence.
Loimer N, Hofmann P, Chaudhry HR. J Psychiatr Res. 1992 Jan; 26(1):39-43.
Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria. [Am J Drug Alcohol Abuse. 1989]
Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria.
Kosten TA, Jacobsen LK, Kosten TR. Am J Drug Alcohol Abuse. 1989; 15(3):237-50.
Review Opiate withdrawal. [Addiction. 1994]
Review Opiate withdrawal.
Farrell M. Addiction. 1994 Nov; 89(11):1471-5.
Review The Clinical Opiate Withdrawal Scale (COWS). [J Psychoactive Drugs. 2003]
Review The Clinical Opiate Withdrawal Scale (COWS).
Wesson DR, Ling W. J Psychoactive Drugs. 2003 Apr-Jun; 35(2):253-9.

See reviews... See all...

Cited by 1 PubMed Central article

Review Pharmacologic treatments for opioid dependence: detoxification and maintenance options. [Dialogues Clin Neurosci. 2007]
Review Pharmacologic treatments for opioid dependence: detoxification and maintenance options.
Kleber HD. Dialogues Clin Neurosci. 2007; 9(4):455-70.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Use of naloxone in the assessment of opiate dependence.
Use of naloxone in the assessment of opiate dependence.
Life Sci. 1991 ;49(24):1809-14.

PubMed
Comparison of ligand- and structure-based virtual screening on the DUD data set.
Comparison of ligand- and structure-based virtual screening on the DUD data set.
J Chem Inf Model. 2009 Feb ;49(2):209-31.

PubMed
Neurostimulation approaches to primary headache disorders.
Neurostimulation approaches to primary headache disorders.
Curr Opin Neurol. 2009 Jun ;22(3):262-8.

PubMed
Intercellular communication through gap junctions: a potential role in pharmacom...
Intercellular communication through gap junctions: a potential role in pharmacomechanical coupling and syncytial tissue contraction in vascular smooth muscle isolated from the human corpus cavernosum.
Life Sci. 1991 ;49(24):PL195-200.

PubMed
Dental erosion and severe tooth decay related to soft drinks: a case report and ...
Dental erosion and severe tooth decay related to soft drinks: a case report and literature review.
J Zhejiang Univ Sci B. 2009 May ;10(5):395-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: