South Med J. 2009 Jun;102(6):615-9.

Cardiac complications after smallpox vaccination.

Source

Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree Street, 5th floor Medical Office Tower, Office 4410, Atlanta, GA 30308, USA. luismora71@hotmail.com

Abstract

In 2002, the US Federal government initiated a campaign to vaccinate military personnel and members of the civilian population against smallpox to counter a possible bioterrorism attack. More than 1,200,000 military personnel and approximately 40,000 civilians have been vaccinated since that time. The incidence of myopericarditis in these vaccinees has clearly exceeded calculated background rates and has prompted discussion about cardiac inflammation and other potential vaccine-associated cardiac complications such as dilated cardiomyopathy (DCM) and myocardial ischemia. Although it seems reasonable to predict that some cases of smallpox-associated myopericarditis will progress to DCM, only small numbers have been documented so far, and a causal relationship is difficult to ascertain. With regard to myocardial ischemia, both historical and current data do not suggest a causal association with the vaccine. We describe a case report of myopericarditis following smallpox immunization and provide a review of all cardiac complications associated with vaccination.

Comment in

South Med J. 2009 Jun;102(6):561-2.

PMID:: 19434043; [PubMed - indexed for MEDLINE]

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Smallpox Vaccine

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Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel. [JAMA. 2003]
Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel.
Halsell JS, Riddle JR, Atwood JE, Gardner P, Shope R, Poland GA, Gray GC, Ostroff S, Eckart RE, Hospenthal DR, et al. JAMA. 2003 Jun 25; 289(24):3283-9.
Update: cardiac and other adverse events following civilian smallpox vaccination--United States, 2003. [MMWR Morb Mortal Wkly Rep. 2003]
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Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2003 Jul 11; 52(27):639-42.
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Morgan J, Roper MH, Sperling L, Schieber RA, Heffelfinger JD, Casey CG, Miller JW, Santibanez S, Herwaldt B, Hightower P, et al. Clin Infect Dis. 2008 Mar 15; 46 Suppl 3:S242-50.
Review Smallpox vaccination and myopericarditis: a clinical review. [J Am Coll Cardiol. 2004]
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