South Med J. 2009 Jun;102(6):649-52.

Vitamin D as adjunctive therapy in refractory pulmonary tuberculosis: a case report.

Yamshchikov AV, Oladele A, Leonard MK Jr, Blumberg HM, Ziegler TR, Tangpricha V.

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Division of Infectious Diseases, Department of Medicine, Emory University-School of Medicine, Atlanta, GA 30303, USA. ayamshc@emory.edu

Abstract

Vitamin D regulates calcium homeostasis in the body and may play a major role in regulating immune responses to tuberculosis (TB). Pilot studies suggest that vitamin D supplementation may improve outcomes in pulmonary TB (PTB), but clinical evidence using vitamin D in TB treatment is limited. We present a case of vitamin D deficiency in a woman with refractory drug-susceptible PTB. Antituberculous therapy and the correction of vitamin D deficiency resulted in clinical and microbiologic improvement at month 13 of her treatment. The basis for vitamin D/TB interactions and a brief literature review are discussed. Data from controlled trials are needed to evaluate the efficacy of vitamin D as adjunctive TB therapy.

PMID:: 19434014; [PubMed - indexed for MEDLINE]
PMCID: PMC2892733

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