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    Antivir Ther. 2009;14(2):143-54.

    Management of hepatitis C virus genotype 2 or 3 infection: treatment optimization on the basis of virological response.

    Zeuzem S, Rizzetto M, Ferenci P, Shiffman ML.

    Source

    JW Goethe University Hospital, Frankfurt, Germany.

    Abstract

    Current guidelines recommend a full 24-week regimen for all patients undergoing treatment for genotype 2 or 3 hepatitis C virus (HCV) infection. Recent data from two large randomized studies, one with pegylated interferon-alpha2a plus ribavirin (RBV) and one with pegylated interferon-alpha2b plus RBV assessed treatment duration and on-treatment predictors, such as rapid virological response (RVR; HCV RNA <50 IU/ml at week 4) or sustained virological response rates. Overall, these studies have shown that abbreviated regimens are generally less effective than standard 24-week regimens in genotype 2 or 3 patients because of a higher rate of relapse. However, abbreviated treatment might be offered to selected patients with an RVR provided that they have a low baseline viral load and minimal hepatic fibrosis.

    PMID:
    19430089
    [PubMed - indexed for MEDLINE]

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