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J Mol Endocrinol. 2009 Nov;43(5):187-95. doi: 10.1677/JME-09-0016. Epub 2009 May 8.

IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes.

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  • 1Department of Biology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.


Recent genome-wide association (GWA) studies of type 2 diabetes (T2D) have implicated IGF2 mRNA-binding protein 2 (IMP2/IGF2BP2) as one of the several factors in the etiology of late onset diabetes. IMP2 belongs to a family of oncofetal mRNA-binding proteins implicated in RNA localization, stability, and translation that are essential for normal embryonic growth and development. This review provides a background to the IMP protein family with an emphasis on human IMP2, followed by a closer look at the GWA studies to evaluate the significance, if any, of the proposed correlation between IMP2 and T2D.

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