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Bioinformatics. 2009 Jul 1;25(13):1709-10. doi: 10.1093/bioinformatics/btp304. Epub 2009 May 7.

FlexServ: an integrated tool for the analysis of protein flexibility.

Author information

  • 1Joint IRB-BSC Program on Computational Biology, Institute of Research in Biomedicine, Barcelona Science Park, Josep Samitier 1-5, Barcelona, Spain.

Abstract

SUMMARY:

FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann's indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics.

AVAILABILITY:

http://mmb.pcb.ub.es/FlexServ; http://www.inab.org

PMID:
19429600
[PubMed - indexed for MEDLINE]
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