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Biochimie. 2009 Aug;91(8):1053-7. doi: 10.1016/j.biochi.2009.04.019. Epub 2009 May 9.

Metabolic phenotyping of genetically modified mice: An NMR metabonomic approach.

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  • 1Centre de Recerca Biomèdica, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Spain.


Monocyte chemoattractant protein-1 (MCP-1) plays a relevant role in macrophage migration but recent findings suggest an additional role in lipid and glucose metabolism. We report the use of (1)H NMR spectroscopy as a useful complementary method to assess the metabolic function of this gene in a comparative strategy. This metabonomic analysis was rapid, simple, quantitative and reproducible, and revealed a suggestive relationship between the expression of the MCP-1 gene and hepatic glucose and taurine concentrations. This approach should be considered in genetically modified mice when a metabolic alteration is suspected, or in routine assessment of metabolic phenotype.

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