Chukvelutins A-C, 16-norphragmalin limonoids with unprecedented skeletons from Chukrasia tabularis var. velutina

Jun Luo; Jun-Song Wang; Jian-Guang Luo; Xiao-Bing Wang; Ling-Yi Kong

doi:10.1021/ol900589h

Chukvelutins A-C, 16-norphragmalin limonoids with unprecedented skeletons from Chukrasia tabularis var. velutina

Org Lett. 2009 Jun 4;11(11):2281-4. doi: 10.1021/ol900589h.

Authors

Jun Luo¹, Jun-Song Wang, Jian-Guang Luo, Xiao-Bing Wang, Ling-Yi Kong

Affiliation

¹ Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.

PMID: 19425541
DOI: 10.1021/ol900589h

Abstract

Three new 16-norphragmalin limonoids, chukvelutins A-C (1-3), were isolated from the stem bark of Chukrasia tabularis var. velutina, which possess unprecedented skeletons, featured with a characteristic ketal moiety between the phragmalin skeleton and a biosynthetically extended isobutyryl group at C-15. Their structures were elucidated by extensive spectroscopic technologies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Limonins / chemistry*
Limonins / isolation & purification*
Meliaceae / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
Plants, Medicinal / chemistry*

Substances

Limonins
chukvelutin A
chukvelutin B
chukvelutin C