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(1) On July 1, 2005, several leading biomedical journals decided to publish only the results of clinical trials that had been listed in approved registries; (2) More and more clinical trials are now being recorded in a variety of national and international registries by an increasing number of private and public institutions; (3) The international network of WHO-approved registries, operational since 2007, provides access to more than 60 000 trials (in April 2008), but there is still no single comprehensive international registry of clinical trials; (4) The US registry (ClinicalTrials.gov) is publicly accessible, but the public does not have online access to the European registry (EudraCT); (5) These registries would be more useful if registration were transparent and mandatory in all countries where clinical trials are conducted; (6) Patients who agree to participate in a clinical trial should first verify that the study is listed in a WHO-approved registry and that the authors have committed to publish the results.
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