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J Appl Physiol (1985). 2009 Jul;107(1):8-16. doi: 10.1152/japplphysiol.00343.2009. Epub 2009 May 7.

The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise.

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  • 1Dept. of Health and Exercise Science, Colorado State Univ., 200 Moby B Complex, Fort Collins, CO 80523-1582, USA.


The importance of mitochondrial dysfunctions in the progression of chronic disease has been well established. Patients with chronic diseases are often prescribed a variety of medications, many of which have been shown to induce mitochondrial dysfunction. Exercise is a known stimulus for mitochondrial biogenesis and also recommended to patients as a lifestyle modification to supplement drug therapy. However, the potential interference of those drugs with mitochondrial adaptations to exercise has not been thoroughly investigated. This review provides a summary and discussion of known and potential interactions of commonly consumed drugs with exercise-induced mitochondrial adaptations.

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