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Gastrointest Endosc Clin N Am. 2009 Apr;19(2):299-307. doi: 10.1016/j.giec.2009.02.002.

New endoscopic and cytologic tools for cancer surveillance in the digestive tract.

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  • 1Department of Mechanical Engineering, University of Washington, Seattle, 98195, USA. eseibel@u.washington.edu


Cancer surveillance is an increasing part of everyday practice in gastrointestinal Endoscopy due to the identification of high-risk groups from genetic and biomarker testing, genealogic and epidemiologic studies, and the increasing number of cancer survivors. An efficient surveillance program requires a cost-effective means for image-guided cancer detection and biopsy. A laser-based tethered-capsule endoscope with enhanced spectral imaging is introduced for unsedated surveillance of the lower esophagus. An ultrathin version of this same endoscope technology provides a 1.2-mm guidewire with imaging capability and cannula-style tools are proposed for image-guided biopsy. Advanced three-dimensional cell visualization techniques are described for increasing the sensitivity of early cancer diagnosis from hematoxylin-stained cells sampled from the pancreatic and biliary ducts.

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