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J Altern Complement Med. 2009 May;15(5):523-9. doi: 10.1089/acm.2008.0402.

Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial.

Author information

  • 1Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA. michael.thompson@phci.org

Abstract

OBJECTIVES:

To determine if exogenous S-adenosyl-l-methionine (AdoMet), a commonly used nutritional supplement, increases the level of plasma homocysteine (Hcy), a potential cardiovascular risk factor, in healthy human subjects.

DESIGN:

Double-blind, placebo-controlled, randomized clinical trial.

SETTING:

Mayo Clinic, Rochester, Minnesota.

SUBJECTS:

Fifty-two (52) healthy human volunteers.

INTERVENTION:

Subjects received placebo or AdoMet (800 mg per day) for 4 weeks. Hcy levels were measured before and after administration of AdoMet or placebo.

OUTCOME MEASURES:

The primary outcome measure was change in Hcy level. Secondary outcome measures included an interim Hcy determination (at 2 weeks) and changes in levels of high-sensitivity C-reactive protein (hsCRP), lipids, and alanine aminotransferase.

RESULTS:

There was no statistically significant change in Hcy between groups. Similarly, no statistically significant differences in change in Hcy or hsCRP levels were observed at 2 or 4 weeks. There was a small but statistically significant increase (p < 0.04) in alanine aminotransferase at week 2 and a statistically significant decrease (p < 0.04) in total cholesterol in the AdoMet group compared with the placebo group.

CONCLUSIONS:

AdoMet at a daily dose of 800 mg for 4 weeks does not appear to significantly affect Hcy levels in the blood.

PMID:
19422296
[PubMed - indexed for MEDLINE]
PMCID:
PMC2875864
Free PMC Article

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