Abstract
Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive osteoclastogenic feedback loop.
MeSH terms
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Animals
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Bone Resorption / metabolism
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CREB-Binding Protein / metabolism
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Cell Differentiation
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Gene Knockdown Techniques
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Iron / metabolism*
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Mice
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Mitochondria / metabolism
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Organelle Biogenesis
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Osteoclasts / metabolism*
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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Reactive Oxygen Species / metabolism
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Receptors, Transferrin / metabolism
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Trans-Activators / deficiency*
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Trans-Activators / genetics
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Transcription Factors
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Transferrin / metabolism
Substances
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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Ppargc1a protein, mouse
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Reactive Oxygen Species
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Receptors, Transferrin
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Tfrc protein, mouse
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Trans-Activators
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Transcription Factors
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Transferrin
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Iron
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CREB-Binding Protein
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Crebbp protein, mouse