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J Proteome Res. 2009 Jul;8(7):3666-74. doi: 10.1021/pr800937k.

Identification of natural MHC class II presented phosphopeptides and tumor-derived MHC class I phospholigands.

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  • 1Department of Immunology, Institute for Cell Biology, University of Tübingen, D-72076 Tübingen, Germany.


MHC molecules present protein-derived peptides to T lymphocytes. By developing TiO2-based microcentrifugation columns, we identified the first phosphorylated MHC class I ligands from tumor tissue (renal cell carcinoma) and, by comparison to healthy renal tissue, found one Brf1-derived ligand as potentially tumor-associated. We further discovered the first natural phosphorylated MHC class II ligands. They revealed several novel phosphorylation sites of significant transmembrane receptors, such as Frizzled 6, CXCR4 and CD20.

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