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Angew Chem Int Ed Engl. 2009;48(23):4174-9. doi: 10.1002/anie.200805998.

All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery.

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  • 1Department of Chemistry, Yonsei University, Seoul 120-749, Korea.

Abstract

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.

PMID:
19408274
[PubMed - indexed for MEDLINE]
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