Send to

Choose Destination
See comment in PubMed Commons below
Angew Chem Int Ed Engl. 2009;48(23):4174-9. doi: 10.1002/anie.200805998.

All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery.

Author information

  • 1Department of Chemistry, Yonsei University, Seoul 120-749, Korea.


Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk