Visualization of the pattern of hippocampal surface deformation in subjects with very mild DAT compared with non-demented subjects. Panel a shows the left and right hippocampi from the top (dorsal surface), while panel b shows the left and right hippocampi from the bottom (ventral surface). Panels c and d show the left and right hippocampi from a perspective slightly above and to the left and right of a midline plane, respectively, to highlight deformities along the lateral body of the left and right hippocampi that approximate the CA1 subfield. Boundaries between the three zones of the hippocampal surface (i.e., CA1, subiculum, and remainder) are drawn in black and all three zones are labeled. The flame coloring represents the difference between the mean surface of the subjects with very mild DAT and the mean surface of non-demented subjects. Inward variation of the hippocampal surface is represented by cooler colors (i.e., blue to purple), while outward variation is represented by warmer colors (i.e., orange to red). [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]

Correlations of hippocampal subfield surface deformation, by surface vertices, between the LMK + HDBM and the FS + LDDMM mapping pipeline for the overlapping 79 subjects. Only the surface vertices that show significant correlations were colored according to the correlation values, others were colored as yellow–green. Panel a shows dorsal view (from the top) and panel b shows ventral view (from the bottom) of the hippocampus. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]

Scatter plots of hippocampal volume and surface deformation measures derived from FS + LDDMM pipeline versus measures derived from the LMK + HDBM pipeline in the overlapping 79 subjects. Correlation plots (columns a, b) and Bland-Alt-man plots (columns c, d) for volume (top row), CA1 deformation (second row), subiculum deformation (third row), and remainder (bottom row) are shown. Columns a and c are for left hemisphere measures and columns b and d are for right hemisphere measures. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]