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    Nat Cell Biol. 2009 May;11(5):538-40.

    Smurf1 zaps the talin head.

    Critchley DR.

    Abstract

    Focal adhesion turnover is essential for cell migration. New results show that the talin head liberated from talin by calpain II cleavage has a key role in these events, and that its levels are tightly regulated by Smurf1-mediated ubiquitylation counteracted by Cdk5-mediated phosphorylation.

    PMID:
    19404335
    [PubMed - indexed for MEDLINE]

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