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    J Virol. 2009 Jul;83(14):7353-6. Epub 2009 Apr 29.

    Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells.

    Knouf EC, Metzger MJ, Mitchell PS, Arroyo JD, Chevillet JR, Tewari M, Miller AD.

    Source

    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.

    Abstract

    The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, most frequently in humans with a defect in the antiviral defense protein RNase L, suggesting a role for XMRV in prostate carcinogenesis. However, XMRV has not been found in prostate carcinoma cells. Here we show that 22Rv1 prostate carcinoma cells produce high-titer virus that is nearly identical in properties and sequence to XMRV isolated by others and consist primarily of a single clone of cells with at least 10 integrated copies of XMRV, warranting further study of a possible role for XMRV integration in carcinogenesis.

    PMID:
    19403664
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2704771
    Free PMC Article

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