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Emerg Infect Dis. 2009 May;15(5):741-8. doi: 10.3201/eid1505.071299.

CTX-M beta-lactamases in Escherichia coli from community-acquired urinary tract infections, Cambodia.

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  • 1Institut Pasteur du Cambodge, Phnom Penh, Cambodia. etienne.ruppe@gmail.com

Abstract

Despite the recent global spread of CTX-M beta-lactamases in Escherichia coli isolates from community-acquired urinary tract infections (CA-UTIs), their dissemination has been little studied in developing countries. In a 2-year prospective study, we documented the prevalence of extended-spectrum beta-lactamases (ESBLs) in E. coli that were responsible for CA-UTIs in Phnom-Penh, Cambodia. Ninety-three E. coli strains were included. We observed a high prevalence of resistance to amoxicillin (88.2% of strains), cotrimoxazole (75.3%), ciprofloxacin (67.7%), gentamicin (42.5%), and third-generation cephalosporins (37.7%). A total of 34 strains carried ESBLs, all of which were CTX-M type. CTX-M carriage was associated with resistance to fluoroquinolones and aminoglycosides. U using repetitive extragenic palindromic-PCR, we identified 4 clusters containing 9, 8, 3, and 2 strains. The prevalence of CTX-M beta-lactamases has reached a critical level in Cambodia, which highlights the need for study of their spread in developing countries.

PMID:
19402960
[PubMed - indexed for MEDLINE]
PMCID:
PMC2687024
Free PMC Article
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