Dis Aquat Organ. 2009 Feb 25;83(3):257-60.

Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles.

Garner TW, Garcia G, Carroll B, Fisher MC.

Source

Institute of Zoology, Zoological Society of London, Regent's Park, London NW1 4RY, UK. trent.garner@ioz.ac.uk

Abstract

Batrachochytrium dendrobatidis (Bd) is a global threat to amphibian biodiversity. Current calls for conservation through captive breeding require that efficient and reliable antifungal treatments be developed for target species. Here we confirm that the antifungal itraconazole is an effective treatment for infection in larval Alytes muletensis. Exceptionally low doses applied as few as 7 times were effective at clearing infection from tadpoles for up to 28 d after treatment. However, we cannot recommend itraconazole as a treatment for this species as depigmentation of tadpoles was observed. Further research is required to determine the putative hepatotoxicity of this treatment.

PMID:: 19402457; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Fungal Infections - MedlinePlus Health Information

Molecular Biology Databases

Itraconazole - HSDB

Supplemental Content

Related citations

Developing a safe antifungal treatment protocol to eliminate Batrachochytrium dendrobatidis from amphibians. [Med Mycol. 2011]
Developing a safe antifungal treatment protocol to eliminate Batrachochytrium dendrobatidis from amphibians.
Martel A, Van Rooij P, Vercauteren G, Baert K, Van Waeyenberghe L, Debacker P, Garner TW, Woeltjes T, Ducatelle R, Haesebrouck F, et al. Med Mycol. 2011 Feb; 49(2):143-9. Epub 2010 Aug 18.
Review Treatment of chytridiomycosis requires urgent clinical trials. [Dis Aquat Organ. 2010]
Review Treatment of chytridiomycosis requires urgent clinical trials.
Berger L, Speare R, Pessier A, Voyles J, Skerratt LF. Dis Aquat Organ. 2010 Nov; 92(2-3):165-74.
A zoospore inhibition technique to evaluate the activity of antifungal compounds against Batrachochytrium dendrobatidis and unsuccessful treatment of experimentally infected green tree frogs (Litoria caerulea) by fluconazole and benzalkonium chloride. [Res Vet Sci. 2009]
A zoospore inhibition technique to evaluate the activity of antifungal compounds against Batrachochytrium dendrobatidis and unsuccessful treatment of experimentally infected green tree frogs (Litoria caerulea) by fluconazole and benzalkonium chloride.
Berger L, Speare R, Marantelli G, Skerratt LF. Res Vet Sci. 2009 Aug; 87(1):106-10. Epub 2008 Dec 30.
Impacts of Batrachochytrium dendrobatidis infection on tadpole foraging performance. [Ecohealth. 2009]
Impacts of Batrachochytrium dendrobatidis infection on tadpole foraging performance.
Venesky MD, Parris MJ, Storfer A. Ecohealth. 2009 Dec; 6(4):565-75. Epub 2010 Feb 5.
Review Global emergence of Batrachochytrium dendrobatidis and amphibian chytridiomycosis in space, time, and host. [Annu Rev Microbiol. 2009]
Review Global emergence of Batrachochytrium dendrobatidis and amphibian chytridiomycosis in space, time, and host.
Fisher MC, Garner TW, Walker SF. Annu Rev Microbiol. 2009; 63:291-310.

See reviews... See all...

Cited by 4 PubMed Central articles

Nothing a hot bath won't cure: infection rates of amphibian chytrid fungus correlate negatively with water temperature under natural field settings. [PLoS One. 2011]
Nothing a hot bath won't cure: infection rates of amphibian chytrid fungus correlate negatively with water temperature under natural field settings.
Forrest MJ, Schlaepfer MA. PLoS One. 2011; 6(12):e28444. Epub 2011 Dec 21.
Mitigating amphibian disease: strategies to maintain wild populations and control chytridiomycosis. [Front Zool. 2011]
Mitigating amphibian disease: strategies to maintain wild populations and control chytridiomycosis.
Woodhams DC, Bosch J, Briggs CJ, Cashins S, Davis LR, Lauer A, Muths E, Puschendorf R, Schmidt BR, Sheafor B, et al. Front Zool. 2011 Apr 18; 8(1):8. Epub 2011 Apr 18.
Within- and among-population variation in chytridiomycosis-induced mortality in the toad Alytes obstetricans. [PLoS One. 2010]
Within- and among-population variation in chytridiomycosis-induced mortality in the toad Alytes obstetricans.
Tobler U, Schmidt BR. PLoS One. 2010 Jun 2; 5(6):e10927. Epub 2010 Jun 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subseq...
Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles.
Dis Aquat Organ. 2009 Feb 25 ;83(3):257-60.

PubMed
Cost-effective workup for tonsillitis. Testing, treatment, and potential complic...
Cost-effective workup for tonsillitis. Testing, treatment, and potential complications.
Postgrad Med. 2003 Mar ;113(3):115-8, 121.

PubMed
The role of bacterial interference in otitis, sinusitis and tonsillitis.
The role of bacterial interference in otitis, sinusitis and tonsillitis.
Otolaryngol Head Neck Surg. 2005 Jul ;133(1):139-46.

PubMed
Sore throat, tonsillitis, and adenoiditis.
Sore throat, tonsillitis, and adenoiditis.
Med Clin North Am. 1999 Jan ;83(1):75-83, viii.

PubMed
Evolutionary constraints on structural similarity in orthologs and paralogs.
Evolutionary constraints on structural similarity in orthologs and paralogs.
Protein Sci. 2009 Jun ;18(6):1306-15.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: