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Br J Cancer. 2009 May 19;100(10):1603-7. doi: 10.1038/sj.bjc.6605058. Epub 2009 Apr 28.

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer.

Author information

  • 1Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden. j.nilsson@vumc.nl

Abstract

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.

PMID:
19401683
[PubMed - indexed for MEDLINE]
PMCID:
PMC2696767
Free PMC Article
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