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    Int J Neuropsychopharmacol. 2009 Jul;12(6):851-60. Epub 2009 Apr 29.

    Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients.

    Rao JS, Rapoport SI, Kim HW.

    Source

    Brain Physiology and Metabolism Section, NIA, NIH, Bethesda, MD 20892, USA. jrao@grc.nia.nih.gov

    Abstract

    Overactivation of G-protein-mediated functions and altered G-protein regulation have been reported in bipolar disorder (BD) brain. Further, drugs effective in treating BD are reported to up-regulate expression of G-protein receptor kinase (GRK) 3 in rat frontal cortex. We therefore hypothesized that some G-protein subunits and GRK levels would be reduced in the brain of BD patients. We determined protein and mRNA levels of G-protein beta and gamma subunits, GRK2, and GRK3 in post-mortem frontal cortex from 10 BD patients and 10 age-matched controls by using immunoblots and real-time RT-PCR. There were statistically significant decreases in protein and mRNA levels of G-protein subunits beta and gamma and of GRK3 in BD brain but not a significant difference in the GRK2 level. Decreased expression of G-protein subunits and of GRK3 may alter neurotransmission, leading to disturbed cognition and behaviour in BD.

    PMID:
    19400979
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2738976
    Free PMC Article

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