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    Angew Chem Int Ed Engl. 2009;48(21):3854-7. doi: 10.1002/anie.200900185.

    Rational design of an organometallic glutathione transferase inhibitor.

    Ang WH, Parker LJ, De Luca A, Juillerat-Jeanneret L, Morton CJ, Lo Bello M, Parker MW, Dyson PJ.

    Source

    Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

    Abstract

    Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.

    PMID:
    19396894
    [PubMed - indexed for MEDLINE]

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