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Angew Chem Int Ed Engl. 2009;48(21):3854-7. doi: 10.1002/anie.200900185.

Rational design of an organometallic glutathione transferase inhibitor.

Author information

  • 1Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

Abstract

Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.

PMID:
19396894
[PubMed - indexed for MEDLINE]
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