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Virchows Arch. 2010 Feb;456(2):153-66. doi: 10.1007/s00428-009-0776-0. Epub 2009 Apr 28.

Soft tissue sarcomas with non-EWS translocations: molecular genetic features and pathologic and clinical correlations.

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  • 1Department of Pathology, Royal Marsden NHS Foundation Trust, London, UK.


Many soft tissue sarcoma subtypes have consistent chromosomal translocations with novel fusion genes, which result in disordered cellular function. The microscopic appearances, immunophenotype and behaviour of such tumours relate to the genetic events to a variable extent. This paper reviews the molecular pathology and related morphological and clinical features of sarcomas with non-EWS translocations. These include synovial sarcoma, alveolar rhabdomyosarcoma, alveolar soft part sarcoma, dermatofibrosarcoma protuberans, low-grade fibromyxoid sarcoma, infantile fibrosarcoma and inflammatory myofibroblastic tumour.

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