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J Infect Chemother. 2009 Apr;15(2):62-9. doi: 10.1007/s10156-009-0669-9. Epub 2009 Apr 25.

Loop-mediated isothermal amplification (LAMP): a rapid, accurate, and cost-effective diagnostic method for infectious diseases.

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  • 1Biochemical Research Laboratory, Research and Development Division, Eiken Chemical Co., Ltd., 1381-3 Shimoishigami, Ohtawara, Tochigi, 324-0036, Japan. Yasuyoshi_Mori@eiken.co.jp

Abstract

Loop-mediated isothermal amplification (LAMP) is an established nucleic acid amplification method offering rapid, accurate, and cost-effective diagnosis of infectious diseases. This technology has been developed into commercially available detection kits for a variety of pathogens including bacteria and viruses. The current focus on LAMP methodology is as a diagnostic system to be employed in resource-limited laboratories in developing countries, where many fatal tropical diseases are endemic. The combination of LAMP and novel microfluidic technologies such as Lab-on-a-chip may facilitate the realization of genetic point-of-care testing systems to be used by both developed and developing countries in the near future. This review will describe the historical, current, and future developments of such technologies.

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