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Curr Opin Cell Biol. 2009 Jun;21(3):403-8. doi: 10.1016/j.ceb.2009.03.005. Epub 2009 Apr 23.

Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs.

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  • 1Department of Molecular and Cellular Biology & Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721-0206, USA.

Abstract

The control of translation and mRNA degradation plays a key role in the regulation of eukaryotic gene expression. In the cytosol, mRNAs engaged in translation are distributed throughout the cytosol, while translationally inactive mRNAs can accumulate in P bodies, in complex with mRNA degradation and translation repression machinery, or in stress granules, which appear to be mRNAs stalled in translation initiation. Here we discuss how these different granules suggest a dynamic model for the metabolism of cytoplasmic mRNAs wherein they cycle between different mRNP states with different functional properties and subcellular locations.

PMID:
19394210
[PubMed - indexed for MEDLINE]
PMCID:
PMC2740377
Free PMC Article

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