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Autoimmun Rev. 2009 Jul;8(8):650-3. doi: 10.1016/j.autrev.2009.02.013. Epub 2009 Feb 12.

Myelin peptides in multiple sclerosis.

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  • 1Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Abstract

The development of specific therapies for organ-specific autoimmune diseases requires the identification of relevant immunogenic epitopes, recognized by both pathogenic T cells and autoantibodies. Here, we review the most relevant studies focused in the identification of peptides in multiple sclerosis (MS) and the distinct T cell reactivity induced in patients compared to controls. Only a few studies reported significant differences in terms of T cell reactivity to them. The current knowledge on this issue, and the diagnostic and therapeutic possibilities opened by the identification of pathogenic MS epitopes are discussed in this paper.

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