Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Expert Opin Biol Ther. 2009 May;9(5):593-608. doi: 10.1517/14712590902911412 .

From lab to bedside: emerging clinical applications of thymosin alpha 1.

Author information

  • 1Department of Biochemistry & Molecular Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Abstract

BACKGROUND:

Thymosin alpha(1) (Talpha(1)), a synthetic version of a thymic-derived biological response modifier was the first of the thymosins in clinical use. Talpha(1) is approved in over 35 countries for the treatment of hepatitis B and C, and as an immune stimulant and adjuvant. Talpha(1) is also in late-stage clinical testing in the United States and Europe for hepatitis C and stage IV melanoma.

OBJECTIVE/METHODS:

Novel applications and other recently completed trials point to much broader clinical applications of Talpha(1) in the treatment of life-threatening and chronic diseases, and are the subject of this review.

RESULT/CONCLUSIONS:

The most recent reports of clinical trials with Talpha(1) are pointing to important, hitherto unrecognized, applications in a number of diseases and disorders, including septic shock, acute respiratory distress syndrome, peritonitis, acute cytomegalovirus infection, TB, severe acute respiratory syndrome, and lung infections in critically ill patients. It is also emerging as a promising chemoprotection agent in patients undergoing chemotherapy.

PMID:
19392576
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Informa Healthcare
    Loading ...
    Write to the Help Desk