A theoretical approach to the description of the Soret effect in binary nonpolar liquids is proposed. The temperature gradient of the partial pressure is determined as the driving force of thermal diffusion. The hard-sphere fluid is chosen as a reference system and an explicit relation for the Soret coefficient is found. Two additive contributions owing to steric repulsions and attractive interactions form the so-called chemical contribution to S_{T} [C. Debuschewitz and W. Köhler, Phys. Rev. Lett. 87, 055901 (2001)]. The parameters of interparticle interactions are defined with the help of the solvation theory. In particular, the van der Waals constant of cross interactions is expressed via the excess volume of mixture. The proposed theory is applied to the benzene-cyclohexane system. A reasonable agreement of theoretical and experimental results is revealed for the Soret coefficient and its temperature dependence.