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Nat Rev Immunol. 2009 May;9(5):324-37. doi: 10.1038/nri2546.

Immunoregulatory functions of mTOR inhibition.

Author information

  • 1Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. thomsonaw@upmc.edu

Abstract

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of growth factor-induced T cell proliferation. However, it is now evident that the serine/threonine protein kinase mammalian target of rapamycin (mTOR) has an important role in the modulation of both innate and adaptive immune responses. mTOR regulates diverse functions of professional antigen-presenting cells, such as dendritic cells (DCs), and has important roles in the activation of effector T cells and the function and proliferation of regulatory T cells. In this Review, we discuss our current understanding of the mTOR pathway and the consequences of mTOR inhibition, both in DCs and T cells, including new data on the regulation of forkhead box P3 expression.

PMID:
19390566
[PubMed - indexed for MEDLINE]
PMCID:
PMC2847476
Free PMC Article

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