Gerontology. 2009;55(5):491-5. Epub 2009 Apr 23.

CD4+ T cells and immunosenescence--a mini-review.

Source

Trudeau Institute, Saranac Lake, NY 12983, USA.

Abstract

Age-related declines in immune function are associated with reduced humoral responses following vaccination or infection. Central to this defect is a decline in naïve CD4+ T cell function. In this review, we discuss factors intrinsic and extrinsic to the CD4+ T cell compartment that affect host immunity and propose means by which deficient CD4+ T cell function can be fully restored in the aged.

PMID:: 19390162; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Seniors' Health - MedlinePlus Health Information

Supplemental Content

Icon for S. Karger AG, Basel, Switzerland

Save items

Related citations in PubMed

Review Age-associated changes within CD4+ T cells. [Immunol Lett. 2006]
Review Age-associated changes within CD4+ T cells.
Kovaiou RD, Grubeck-Loebenstein B. Immunol Lett. 2006 Sep 15; 107(1):8-14. Epub 2006 Aug 14.
Review CD8 T cells and aging. [Crit Rev Immunol. 2003]
Review CD8 T cells and aging.
Effros RB, Cai Z, Linton PJ. Crit Rev Immunol. 2003; 23(1-2):45-64.
Age-related decline in humoral immunity caused by the selective loss of TH cells and decline in cellular immunity caused by the impaired migration of inflammatory cells without a loss of TDTH cells in SAMP1 mice. [Mech Ageing Dev. 1997]
Age-related decline in humoral immunity caused by the selective loss of TH cells and decline in cellular immunity caused by the impaired migration of inflammatory cells without a loss of TDTH cells in SAMP1 mice.
Toichi E, Hanada K, Hosokawa T, Higuchi K, Hosokawa M, Imamura S, Hosono M. Mech Ageing Dev. 1997 Dec 30; 99(3):199-217.
Review ISCOMATRIX adjuvant: a potent inducer of humoral and cellular immune responses. [Vaccine. 2004]
Review ISCOMATRIX adjuvant: a potent inducer of humoral and cellular immune responses.
Pearse MJ, Drane D. Vaccine. 2004 Jun 23; 22(19):2391-5.
Review Age-related changes in immune reactivity: the influence of intrinsic defects and of a changed composition of the CD4+ T cell compartment. [Exp Clin Immunogenet. 1992]
Review Age-related changes in immune reactivity: the influence of intrinsic defects and of a changed composition of the CD4+ T cell compartment.
Nijhuis EW, Nagelkerken L. Exp Clin Immunogenet. 1992; 9(4):195-202.

See reviews... See all...

Cited by 1 PubMed Central article

Varicella zoster virus latency. [Future Virol. 2011]
Varicella zoster virus latency.
Eshleman E, Shahzad A, Cohrs RJ. Future Virol. 2011 Mar; 6(3):341-355.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

CD4+ T cells and immunosenescence--a mini-review.
CD4+ T cells and immunosenescence--a mini-review.
Gerontology. 2009 ;55(5):491-5. Epub 2009 Apr 23 .

PubMed
5-Lipoxygenase-mediated endogenous DNA damage.
5-Lipoxygenase-mediated endogenous DNA damage.
J Biol Chem. 2009 Jun 19 ;284(25):16799-807. Epub 2009 Apr 23 .

PubMed
Retraction: Correlation between DNA repair capacity in lymphocytes and acute sid...
Retraction: Correlation between DNA repair capacity in lymphocytes and acute side effects to skin during radiotherapy in nasopharyngeal cancer patients.
Clin Cancer Res. 2009 May 15 ;15(10):3642. Epub 2009 Apr 23 .

PubMed
Physicians' use of key functions in electronic health records from 2005 to 2007:...
Physicians' use of key functions in electronic health records from 2005 to 2007: a statewide survey.
J Am Med Inform Assoc. 2009 Jul-Aug ;16(4):465-70. Epub 2009 Apr 23 .

PubMed
A randomized trial comparing telemedicine case management with usual care in old...
A randomized trial comparing telemedicine case management with usual care in older, ethnically diverse, medically underserved patients with diabetes mellitus: 5 year results of the IDEATel study.
J Am Med Inform Assoc. 2009 Jul-Aug ;16(4):446-56. Epub 2009 Apr 23 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: