Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Ann Clin Biochem. 2009 May;46(Pt 3):205-17. doi: 10.1258/acb.2009.009007.

How should proteinuria be detected and measured?

Author information

  • 1Department of Clinical Biochemistry, East Kent Hospital University NHS Foundation Trust, Canterbury, Kent, UK. Edmund.lamb@ekht.nhs.uk

Abstract

Proteinuria is a classic sign of kidney disease and its presence carries powerful prognostic information. Although proteinuria testing is enshrined in clinical practice guidelines, there is surprising variation among such guidelines as to the definition of clinically significant proteinuria. There is also poor agreement as to whether proteinuria should be defined in terms of albumin or total protein loss, with a different approach being used to stratify diabetic and non-diabetic nephropathy. Further, the role of reagent strip devices in the detection and assessment of proteinuria is unclear. This review explores these issues in relation to recent national and international guidelines on chronic kidney disease (CKD) and epidemiological evidence linking proteinuria and clinical outcome. The authors argue that use of urinary albumin measurement as the front-line test for proteinuria detection offers the best chance of improving the sensitivity, quality and consistency of approach to the early detection and management of CKD.

PMID:
19389884
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk