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Dermatol Surg. 2009 May;35(5):765-72. doi: 10.1111/j.1524-4725.2009.01126.x. Epub 2008 Mar 23.

More than 2 decades of treating atypical fibroxanthoma at mayo clinic: what have we learned from 91 patients?

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  • 1Mayo CLinic Rochester, Minnesota 55905, USA.

Abstract

BACKGROUND:

Atypical fibroxanthoma (AFX) typically occurs on the head and neck of elderly white men. Usually considered a malignancy, it is treated with wide local excision (WLE) or total margin control using Mohs micrographic surgery (MMS).

OBJECTIVE:

To determine the most appropriate treatment for this tumor based on a review of cases treated at Mayo Clinic.

METHODS:

We reviewed the medical records of patients with AFX treated at Mayo Clinic from 1980 to 2004.

RESULTS:

We identified 91 patients with 93 tumors. Treatment information was available for 88 tumors (59 treated with MMS, 23 with WLE, and 6 by other means). There were no recurrences in the patients treated with MMS, with a median follow-up of 4.5 years (range 1.0-16.1 years). Two patients treated with WLE had single recurrences, with a median follow-up of 8.7 years (range 1.5-26.3 years).

CONCLUSIONS:

Total microscopic margin control using MMS was the most effective means of treating AFX.

PMID:
19389106
[PubMed - indexed for MEDLINE]
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