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    J Mol Histol. 2009 Apr;40(2):151-5. Epub 2009 Apr 22.

    Expression of EGR-1 in a subset of olfactory bulb dopaminergic cells.

    Akiba N, Jo S, Akiba Y, Baker H, Cave JW.

    Source

    Department of Neurology and Neuroscience, Burke Medical Research Institute, Weill Cornell Medical College, 785 Mamaroneck Ave., White Plains, NY 10605, USA.

    Abstract

    In the adrenal medulla, binding of the immediate early gene (IEG) proteins, EGR-1 (ZIF-268/KROX-24/NGFI-A) and AP-1, to the tyrosine hydroxylase (Th) proximal promoter mediate inducible Th expression. The current study investigated the potential role of EGR-1 in inducible Th expression in the olfactory bulb (OB) since IEGs bound to the AP-1 site in the Th proximal promoter are also necessary for activity-dependent OB TH expression. Immunohistochemical analysis of a naris-occluded mouse model of odor deprivation revealed weak EGR-1 expression levels in the OB glomerular layer that were activity-dependent. Immunofluorescence analysis indicated that a majority of glomerular cells expressing EGR-1 also co-expressed TH, but only small subset of TH-expressing cells contained EGR-1. By contrast, granule cells, which lack TH, exhibited EGR-1 expression levels that were unchanged by naris closure. Together, these finding suggest that EGR-1 mediates activity-dependent TH expression in a subset of OB dopaminergic neurons, and that there is differential regulation of EGR-1 in periglomerular and granule cells.

    PMID:
    19387849
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2765800
    Free PMC Article

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