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Bioorg Med Chem Lett. 2009 May 15;19(10):2627-9. doi: 10.1016/j.bmcl.2009.04.018. Epub 2009 Apr 9.

Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II.

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  • 1BioCryst Pharmaceuticals Inc., Birmingham, AL 35244, United States.


Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (2-4).

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