Dev Cell. 2009 Apr;16(4):491-2.

Epithelial polarity: dual Lkb1 pathways regulate apical microvilli.

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Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA. apb5@cornell.edu

Abstract

The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. In this issue of Developmental Cell, ten Klooster et al. show that the Lkb1/Strad/Mo25 complex mediates two separate pathways, and that both are required for assembly of apical microvilli.

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Dev Cell. 2009 Apr;16(4):551-62.

PMID:: 19386258; [PubMed - indexed for MEDLINE]

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Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. [Dev Cell. 2009]
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, et al. Dev Cell. 2009 Apr; 16(4):551-62.
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. [Cell. 2004]
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.
Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ, Clevers HC. Cell. 2004 Feb 6; 116(3):457-66.
Analysis of the LKB1-STRAD-MO25 complex. [J Cell Sci. 2004]
Analysis of the LKB1-STRAD-MO25 complex.
Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR. J Cell Sci. 2004 Dec 15; 117(Pt 26):6365-75. Epub 2004 Nov 23.
Review LKB1-dependent signaling pathways. [Annu Rev Biochem. 2006]
Review LKB1-dependent signaling pathways.
Alessi DR, Sakamoto K, Bayascas JR. Annu Rev Biochem. 2006; 75:137-63.
Review LKB1 tumor suppressor protein: PARtaker in cell polarity. [Trends Cell Biol. 2004]
Review LKB1 tumor suppressor protein: PARtaker in cell polarity.
Baas AF, Smit L, Clevers H. Trends Cell Biol. 2004 Jun; 14(6):312-9.

See reviews... See all...

Cited by 1 PubMed Central article

The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner. [J Cell Biol. 2010]
The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner.
Garbett D, LaLonde DP, Bretscher A. J Cell Biol. 2010 Oct 18; 191(2):397-413. Epub 2010 Oct 11.

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