Instr Course Lect. 2009;58:677-88.

The use of bone morphogenetic protein in lumbar spine surgery.

Rihn JA, Gates C, Glassman SD, Phillips FM, Schwender JD, Albert TJ.

Source

Department of Orthopedic Surgery, Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Abstract

Creating a solid lumbar spinal fusion remains a challenge. Despite advances in fixation, a pseudarthrosis still may occur. Recently, attention has focused on creating a more biologically favorable environment to enhance fusion rate. Bone morphogenetic proteins (BMPs) are a group of secreted growth factors that belong to the transforming growth factor-beta superfamily. Two recombinant BMP proteins, rhBMP-2 and rhBMP-7 (OP-1), have been used successfully in preclinical and clinical trials and are commercially available for clinical applications.

PMID:: 19385577; [PubMed - indexed for MEDLINE]

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