Kidney graft loss associated with JC polyomavirus nephropathy

Davide Rolla; Claudio G Giacomazzi; Raffaella Gentile; Jean Louis Ravetti; Giuseppe Cannella; Oliviero E Varnier

Kidney graft loss associated with JC polyomavirus nephropathy

J Nephrol. 2009 Mar-Apr;22(2):295-8.

Authors

Davide Rolla¹, Claudio G Giacomazzi, Raffaella Gentile, Jean Louis Ravetti, Giuseppe Cannella, Oliviero E Varnier

Affiliation

¹ Department of Nephrology, Dialysis and Transplantation, San Martino Hospital, and Section of Microbiology CA Romanzi, DISCMIT, University of Genova, Genova, Italy. davide.rolla@hsanmartino.it

PMID: 19384849

Abstract

This is the first case of documented treatment failure of JCV nephritis, despite a reduction of immunosuppressive agents and the use of antiviral therapy. We consistently detected high levels of JCV viremia, which correlated with the progressive deterioration of the graft and caused the final loss of the kidney, suggesting that JCV plays an etiological role in the onset of severe nephropathy in kidney transplant patients.

Publication types

Case Reports

MeSH terms

Antiviral Agents / therapeutic use
Biopsy
DNA, Viral / analysis
Diagnosis, Differential
Female
Follow-Up Studies
Graft Rejection / etiology*
Graft Rejection / pathology
Graft Rejection / therapy
Humans
JC Virus / genetics*
Kidney Failure, Chronic / surgery*
Kidney Transplantation*
Middle Aged
Polymerase Chain Reaction
Polyomavirus Infections / complications*
Polyomavirus Infections / therapy
Polyomavirus Infections / virology
Renal Dialysis / methods
Tumor Virus Infections / complications*
Tumor Virus Infections / therapy
Tumor Virus Infections / virology

Substances

Antiviral Agents
DNA, Viral