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Cell. 2009 Apr 17;137(2):209-11. doi: 10.1016/j.cell.2009.04.002.

Ubiquitin connects with planar cell polarity.

Author information

  • 1Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. marek.mlodzik@mssm.edu

Abstract

Planar cell polarity (PCP) regulates the orientation of cells in epithelia and of mesenchymal cells during gastrulation. In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry.

PMID:
19379687
[PubMed - indexed for MEDLINE]
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