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Cell. 2009 Apr 17;137(2):209-11. doi: 10.1016/j.cell.2009.04.002.

Ubiquitin connects with planar cell polarity.

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  • 1Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.


Planar cell polarity (PCP) regulates the orientation of cells in epithelia and of mesenchymal cells during gastrulation. In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry.

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