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Cell Calcium. 2009 Jun;45(6):554-65. doi: 10.1016/j.ceca.2009.03.011. Epub 2009 Apr 18.

Phosphoinositide regulation of non-canonical transient receptor potential channels.

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  • 1UMDNJ - New Jersey Medical School, Newark, NJ, USA.


Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP(2), or PtdIns(4,5)P(2)] recently emerged as regulators of many TRP channels. Several TRP channels require PIP(2) for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.

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