Send to

Choose Destination
See comment in PubMed Commons below
Neuroimage. 2009 Aug 1;47(1):8-17. doi: 10.1016/j.neuroimage.2009.04.033. Epub 2009 Apr 16.

Predicting the location of entorhinal cortex from MRI.

Author information

  • 1Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA.


Entorhinal cortex (EC) is a medial temporal lobe area critical to memory formation and spatial navigation that is among the earliest parts of the brain affected by Alzheimer's disease (AD). Accurate localization of EC would thus greatly facilitate early detection and diagnosis of AD. In this study, we used ultra-high resolution ex vivo MRI to directly visualize the architectonic features that define EC rostrocaudally and mediolaterally, then applied surface-based registration techniques to quantify the variability of EC with respect to cortical geometry, and made predictions of its location on in vivo scans. The results indicate that EC can be localized quite accurately based on cortical folding patterns, within 3 mm in vivo, a significant step forward in our ability to detect the earliest effects of AD when clinical intervention is most likely to be effective.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk