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Bioorg Med Chem Lett. 2009 May 15;19(10):2661-3. doi: 10.1016/j.bmcl.2009.03.157. Epub 2009 Apr 5.

Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation.

Author information

  • 1Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, L. L. C., Spring House, PA 19477, United States. jralb@msn.com

Abstract

A series of guanidine triazinediones were identified as potent PK1 receptor antagonists. A compound in this series inhibited the PK1 invoked prosecretory response in rat ileum tissue.

PMID:
19375913
[PubMed - indexed for MEDLINE]
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