Hum Hered. 1991;41(3):141-6.

Hereditary disorders in Saguenay-Lac-St-Jean (Quebec, Canada).

Source

SOREP, Université du Québec à Chicoutimi, Canada.

Abstract

Saguenay-Lac-St-Jean is a geographically isolated region located in northeastern Quebec. Opened to the white settlement in 1938, its immigrants mainly came from Charlevoix, another isolated region of Quebec. The prevalence and/or incidence of several autosomal dominant and recessive disorders are very high. The overall birth prevalence of the recessive disorders was calculated at 1/207 living births and the overall carrier rate at 1/7 inhabitants. This situation may be explained by migration and social factors.

PMID:: 1937486; [PubMed - indexed for MEDLINE]

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Genetic Disorders - MedlinePlus Health Information

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Autosomal recessive disorders in Saguenay-Lac-St-Jean, Quebec: study of kinship. [Hum Biol. 1996]
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Cited by 3 PubMed Central articles

A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16. [Am J Hum Genet. 2001]
A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16.
Lee N, Daly MJ, Delmonte T, Lander ES, Xu F, Hudson TJ, Mitchell GA, Morin CC, Robinson BH, Rioux JD. Am J Hum Genet. 2001 Feb; 68(2):397-409. Epub 2001 Jan 10.
Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families. [Am J Hum Genet. 1998]
Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families.
Wang JT, Lin CJ, Burridge SM, Fu GK, Labuda M, Portale AA, Miller WL. Am J Hum Genet. 1998 Dec; 63(6):1694-702.
Review Linkage disequilibrium as a gene-mapping tool. [Am J Hum Genet. 1995]
Review Linkage disequilibrium as a gene-mapping tool.
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