Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genes Dev. 2009 May 1;23(9):1046-51. doi: 10.1101/gad.1777709. Epub 2009 Apr 16.

microRNA-24a is required to repress apoptosis in the developing neural retina.

Author information

  • 1Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California at Berkeley, Berkeley, California 94720, USA.

Abstract

Programmed cell death is important for the proper development of the retina, and microRNAs (miRNAs) may be critical for its regulation. Here, we report that miR-24a is expressed in the neural retina and is required for correct eye morphogenesis in Xenopus. Inhibition of miR-24a during development causes a reduction in eye size due to a significant increase in apoptosis in the retina, whereas overexpression of miR-24a is sufficient to prevent apoptosis. We show that miR-24a negatively regulates the proapoptotic factors caspase9 and apaf1, demonstrating a role for miRNAs in the regulation of apoptosis during normal development.

PMID:
19372388
[PubMed - indexed for MEDLINE]
PMCID:
PMC2682950
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk