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Lab Chip. 2009 May 7;9(9):1282-5. doi: 10.1039/b900753a. Epub 2009 Feb 18.

Biomolecular motor-driven molecular sorter.

Author information

  • 1Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.

Abstract

We have developed a novel, microfabricated, stand-alone microfluidic device that can efficiently sort and concentrate (bio-)analyte molecules by using kinesin motors and microtubules as a chemo-mechanical transduction machine. The device removes hundreds of targeted molecules per second from an analyte stream by translocating functionalized microtubules with kinesin across the stream and concentrating them at a horseshoe-shaped collector. Target biomolecule concentrations increase up to three orders of magnitude within one hour of operation.

PMID:
19370249
[PubMed - indexed for MEDLINE]
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