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Vaccine. 2009 Mar 18;27(13):1923-7. doi: 10.1016/j.vaccine.2009.01.108. Epub 2009 Jan 31.

Influenza in older adults: impact of vaccination of school children.

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  • 1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.


The extent to which immunizing school children reduce the burden of influenza in adults is controversial. We enrolled a systematic sample of adults > or = 50 years hospitalized with respiratory symptoms in two counties, one with and one without a school-based immunization program. We tested all subjects for influenza by polymerase chain reaction. Hospitalizations per 1000 adults aged > or = 50 years were 1.28 (95% CI 0.59, 2.04) in the intervention county and 1.53 (95% CI 0.71, 2.34) in the control county. These rates did not differ significantly except in the subgroup aged 50 -- 64 years where rates in the intervention county were significantly lower.

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