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Biochem Biophys Res Commun. 2009 Jun 12;383(4):421-5. doi: 10.1016/j.bbrc.2009.04.023. Epub 2009 Apr 11.

CpG island methylation pattern in different human tissues and its correlation with gene expression.

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  • 1School of Automation Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.


The study on DNA methylation pattern in different human tissues attracts increasing interest nowadays, but a systematic analysis of CpG island methylation pattern between both somatic tissues and gametocyte is still lacking. In this work, we analyzed the CpG island methylation data of sperm and other 11 somatic tissues from Human Epigenome Project, and found that the CpG island methylation profiles are highly correlated between somatic tissues, while the methylation profile in sperm is quite distinct. Furthermore, we observed that in the six tissues investigated, there is no obvious correlation between the methylation level of promoter CpG islands and corresponding gene expression across different tissues.

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