Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Development. 2009 May;136(9):1399-410. doi: 10.1242/dev.029645.

Drosophila dosage compensation: a complex voyage to the X chromosome.

Author information

  • 1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

Dosage compensation is the crucial process that equalizes gene expression from the X chromosome between males (XY) and females (XX). In Drosophila, the male-specific lethal (MSL) ribonucleoprotein complex mediates dosage compensation by upregulating transcription from the single male X chromosome approximately twofold. A key challenge is to understand how the MSL complex distinguishes the X chromosome from autosomes. Recent studies suggest that this occurs through a multi-step targeting mechanism that involves DNA sequence elements and epigenetic marks associated with transcription. This review will discuss the relative contributions of sequence elements and transcriptional marks to the complete pattern of MSL complex binding.

PMID:
19363150
[PubMed - indexed for MEDLINE]
PMCID:
PMC2674252
Free PMC Article

Images from this publication.See all images (4)Free text

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk