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J Biol Chem. 2009 Jul 10;284(28):18565-9. doi: 10.1074/jbc.R900014200. Epub 2009 Apr 10.

Homeostatic and adaptive responses to zinc deficiency in Saccharomyces cerevisiae.

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  • 1Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA.


Zinc is an essential nutrient and serves as a structural or catalytic cofactor for many proteins. Thus, cells need mechanisms to maintain zinc homeostasis when available zinc supplies decrease. In addition, cells require other mechanisms to adapt intracellular processes to suboptimal levels of zinc. By exploring the transcriptional responses to zinc deficiency, studies of the yeast Saccharomyces cerevisiae have revealed both homeostatic and adaptive responses to low zinc. The Zap1 zinc-responsive transcription factor regulates several genes in yeast, and the identity of these genes has led to new insights regarding how cells respond to the stress of zinc deficiency.

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