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    Bioorg Med Chem Lett. 2009 May 15;19(10):2718-21. Epub 2009 Mar 29.

    Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.

    Mitsuya M, Kamata K, Bamba M, Watanabe H, Sasaki Y, Sasaki K, Ohyama S, Hosaka H, Nagata Y, Eiki J, Nishimura T.

    Source

    Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd, Okubo, Tsukuba, Ibaraki, Japan. morihiro_mitsuya@merck.com

    Abstract

    A novel class of 3,6-disubstituted 2-pyridinecarboxamide derivatives was designed based on X-ray analysis of the 2-aminobenzamide lead class. Subsequent chemical modification led to the discovery of potent GK activators which eliminate potential toxicity concerns associated with an aniline group of the lead structure. Compound 7 demonstrated glucose lowering effect in a rat OGTT model.

    PMID:
    19362831
    [PubMed - indexed for MEDLINE]

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